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From M56 keep right at the fork to stay on M56, follow signs for A5103/City Centre/M60 N & W/M62 W/M61 then follow A5103 to Charlotte Street.
The closest train station to Neo Manchester is Manchester Piccadilly from where you can catch a bus direct to Charlotte Street. Taxis are available at the train station exit.
Manchester Airport has direct train and bus links to Central Manchester.